Post by kickingfrog on Apr 16, 2014 9:07:49 GMT
Non-celiac gluten sensitivity may be an underlying cause of Fibromyalgia (FM) syndrome
Posted by Stella on 15/4/2014
GF board
Paul Whiteley (@paulwhiteleyphd)
Non-celiac gluten sensitivity may be an underlying cause of Fibromyalgia (FM) syndrome.
link.springer.com/article/10.1007/s00296-014-2990-6/fulltext.html
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Rheumatology International
Clinical and Experimental Investigations
© The Author(s) 2014
10.1007/s00296-014-2990-6
Short Communication
Fibromyalgia and non-celiac gluten sensitivity: a description with remission of fibromyalgia
Carlos Isasi1 et al
Received: 10 November 2013
Accepted: 10 March 2014
Published online: 12 April 2014
Abstract
Fibromyalgia (FM) syndrome is a disabling clinical condition of unknown cause, and only symptomatic treatment with limited benefit is available. Gluten sensitivity that does not fulfill the diagnostic criteria for celiac disease (CD) is increasingly recognized as a frequent and treatable condition with a wide spectrum of manifestations that overlap with the manifestations of FM, including chronic musculoskeletal pain, asthenia, and irritable bowel syndrome. The aim of this report was to describe 20 selected patients with FM without CD who improved when placed on a gluten-free diet. An anti-transglutaminase assay, duodenal biopsy, and HLA typing were performed in all cases. CD was ruled out by negative anti-transglutaminase assay results and absence of villous atrophy in the duodenal biopsy. All patients had intraepithelial lymphocytosis without villous atrophy. Clinical response was defined as achieving at least one of the following scenarios: remission of FM pain criteria, return to work, return to normal life, or the discontinuation of opioids. The mean follow-up period was 16 months (range 5–31). This observation supports the hypothesis that non-celiac gluten sensitivity may be an underlying cause of FM syndrome.
...
Posted by Stella on 15/4/2014
GF board
Paul Whiteley (@paulwhiteleyphd)
Non-celiac gluten sensitivity may be an underlying cause of Fibromyalgia (FM) syndrome.
link.springer.com/article/10.1007/s00296-014-2990-6/fulltext.html
**********
Rheumatology International
Clinical and Experimental Investigations
© The Author(s) 2014
10.1007/s00296-014-2990-6
Short Communication
Fibromyalgia and non-celiac gluten sensitivity: a description with remission of fibromyalgia
Carlos Isasi1 et al
Received: 10 November 2013
Accepted: 10 March 2014
Published online: 12 April 2014
Abstract
Fibromyalgia (FM) syndrome is a disabling clinical condition of unknown cause, and only symptomatic treatment with limited benefit is available. Gluten sensitivity that does not fulfill the diagnostic criteria for celiac disease (CD) is increasingly recognized as a frequent and treatable condition with a wide spectrum of manifestations that overlap with the manifestations of FM, including chronic musculoskeletal pain, asthenia, and irritable bowel syndrome. The aim of this report was to describe 20 selected patients with FM without CD who improved when placed on a gluten-free diet. An anti-transglutaminase assay, duodenal biopsy, and HLA typing were performed in all cases. CD was ruled out by negative anti-transglutaminase assay results and absence of villous atrophy in the duodenal biopsy. All patients had intraepithelial lymphocytosis without villous atrophy. Clinical response was defined as achieving at least one of the following scenarios: remission of FM pain criteria, return to work, return to normal life, or the discontinuation of opioids. The mean follow-up period was 16 months (range 5–31). This observation supports the hypothesis that non-celiac gluten sensitivity may be an underlying cause of FM syndrome.
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