CD, the Past, the Present and the Future

[kickingfrog]

CD, the Past, the Present and the Future


Celiac Disease:
The Past and The Present

The Center for Celiac Research and
Mucosal Biology Research Center
University of Maryland School of Medicine
Baltimore, Maryland, U.S.A.

• Several genes are involved
• The most consistent genetic component
depends on the presence of HLA-DQ
(DQ2 and / or DQ8) genes
•.Other genes (not yet identified) account
for 60 % of the inherited component of
the disease
• HLA-DQ2 and / or DQ8 genes are
necessary (No DQ2/8, no Celiac
Disease!) but not sufficient for the
development of the disease

www.victoriaceliac.org/images/up ... resent.pdf

Celiac Disease:
The Future
Alessio Fasano, M.D.
Mucosal Biology Research Center
University of Maryland School of Medicine

Future potential treatments may
include:
– Development of genetically
modified grains
– Inhibitors of tissue
transglutaminase
– Cytokines and/or cytokine
receptors inhibitors
– Detoxification of immunogenic
gliadin peptides via oral
peptidase supplementation
– Oral or intra-nasal celiac
vaccines to induce tolerance
– Inhibitors of the effects of
zonulin on intestinal permeability




www.victoriaceliac.org/images/uploads/Fasano_1_CD_the_Future.pdf

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