Post by kickingfrog on Jan 31, 2011 16:42:03 GMT
Recent advances in coeliac disease (2006)
Gut 2006;55:1037-1046 doi:10.1136/gut.2005.075119
* Recent advances in clinical practice
Recent advances in coeliac disease
1. D A van Heel1,
2. J West2
Correspondence to:
Professor D A van Heel
Institute of Cell and Molecular Science, Barts and The London, Queen Mary’s School of Medicine and Dentistry, Turner St, London E1 2AD, UK; d.vanheel@qmul.ac.uk
....
CONCLUSIONS
Coeliac disease is evidently much more common in Caucasian populations than previously thought
Several large population based studies estimate the prevalence at ~1%.
Further well conducted population based studies suggest that the overall risks of various morbidities and mortality in treated coeliac disease (as diagnosed in current UK practice) are relatively minor.
From an individual perspective, both the clinicians that manage their care and coeliac disease patients now have reasonably precise information to inform them of the actual risks to their health in terms of a range of morbidities and life expectancy.
Published guidelines on the management of coeliac disease are now available although some need updating in the light of these recent studies....... Clearly some individuals may be at higher risk of adverse events than others, and identifying those people who might benefit from further intervention in addition to a gluten free diet is a clinical challenge needing further research.
Equally, others are at low risk of adverse events, questioning the need for ongoing hospital follow up.
Advances in understanding coeliac disease pathogenesis at a basic science level have opened up prospects for novel diagnostics and therapeutics, and made coeliac disease one of the best understood autoimmune disorders. ...
gut.bmj.com/content/55/7/1037.full
*********************
Gut 2006;55:1037-1046 doi:10.1136/gut.2005.075119
* Recent advances in clinical practice
Recent advances in coeliac disease
1. D A van Heel1,
2. J West2
Correspondence to:
Professor D A van Heel
Institute of Cell and Molecular Science, Barts and The London, Queen Mary’s School of Medicine and Dentistry, Turner St, London E1 2AD, UK; d.vanheel@qmul.ac.uk
....
CONCLUSIONS
Coeliac disease is evidently much more common in Caucasian populations than previously thought
Several large population based studies estimate the prevalence at ~1%.
Further well conducted population based studies suggest that the overall risks of various morbidities and mortality in treated coeliac disease (as diagnosed in current UK practice) are relatively minor.
From an individual perspective, both the clinicians that manage their care and coeliac disease patients now have reasonably precise information to inform them of the actual risks to their health in terms of a range of morbidities and life expectancy.
Published guidelines on the management of coeliac disease are now available although some need updating in the light of these recent studies....... Clearly some individuals may be at higher risk of adverse events than others, and identifying those people who might benefit from further intervention in addition to a gluten free diet is a clinical challenge needing further research.
Equally, others are at low risk of adverse events, questioning the need for ongoing hospital follow up.
Advances in understanding coeliac disease pathogenesis at a basic science level have opened up prospects for novel diagnostics and therapeutics, and made coeliac disease one of the best understood autoimmune disorders. ...
gut.bmj.com/content/55/7/1037.full
*********************