Post by kickingfrog on Jan 30, 2011 16:04:39 GMT
Effect of Gluten-free Diet on Preventing Recurrence of Gastroesophageal Reflux Disease-related Symptoms in Adult Celiac Patients With Nonerosive Reflux Disease
Paolo Usai; Roberto Manca; Rosario Cuomo; Maria Antonia Lai; Luigi Russo; Maria Francesca Boi
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Posted: 11/04/2008;
J Gastroenterol Hepatol. 2008;23(9):1368-1372.
© 2008 Blackwell Publishing
Abstract
Background and Aim: In Celiac Disease (CD) the role of a gluten-free diet (GFD) on gastroesophageal reflux disease-related symptoms (GERD-rs) is unclear. The aim of this study was to establish the recurrence of GERD-rs, in CD patients with nonerosive reflux disease (NERD).
Methods: From a total of 105 adult CD patients observed, 29 who presented with the NERD form were enrolled in the study. Thirty non-CD patients with NERD were studied as controls. Recurrence of GERD-rs was clinically assessed at 6, 12, 18, and 24 months follow-up (FU) after withdrawal of initial proton-pump inhibitor (PPI) treatment for 8 weeks.
Results: GERD-rs were resolved in 25 (86.2%) CD patients and in 20 (66.7%) controls after 8 weeks of PPI treatment. In the CD group, recurrence of GERD-rs was found in five cases (20%) at 6 months but in none at 12, 18, and 24 months while in the control group recurrence was found in six of 20 controls (30%), in another six (12/20, 60%), in another three (15/20, 75%), and in another two (17/20, 85%) at 6, 12, 18, and 24 months FU respectively.
Conclusions: The present study is the first to have evaluated the effect of a GFD in the nonerosive form of GERD in CD patients, by means of clinical long-term follow-up, suggesting that GFD could be a useful approach in reducing GERD symptoms and in the prevention of recurrence
www.medscape.com/viewarticle/581691
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Reflux oesophagitis in adult coeliac disease: beneficial effect of a gluten free diet
A Cuomo et al
Conclusion: Coeliac patients have a high prevalence of reflux oesophagitis. That a gluten free diet significantly decreased the relapse rate of GORD symptoms suggests that coeliac disease may represent a risk factor for development of reflux oesophagitis.
gut.bmjjournals.com/cgi/content/abstract/52/4/514
Letter re above:
gut.bmjjournals.com/cgi/eletters/52/4/514#93
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