Post by kickingfrog on Aug 14, 2016 8:00:10 GMT
Dig Dis Sci. 2008 Apr;53(4):972-6. Epub 2007 Oct 13.
Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease.
Silano M1, Volta U, Vincenzi AD, Dessì M, Vincenzi MD; Collaborating Centers of the Italian Registry of the Complications of Coeliac Disease.
Abstract
Patients with celiac disease have an increased rate of enteropathy-associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy.
We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma.
Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P < 0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac disease and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P < 0.001).
The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X(2 )= 4.8 P = 0.01).
These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.
PMID: 17934841 DOI: 10.1007/s10620-007-9952-8
[PubMed - indexed for MEDLINE]
Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease.
Silano M1, Volta U, Vincenzi AD, Dessì M, Vincenzi MD; Collaborating Centers of the Italian Registry of the Complications of Coeliac Disease.
Abstract
Patients with celiac disease have an increased rate of enteropathy-associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy.
We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma.
Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P < 0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac disease and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P < 0.001).
The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X(2 )= 4.8 P = 0.01).
These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.
PMID: 17934841 DOI: 10.1007/s10620-007-9952-8
[PubMed - indexed for MEDLINE]