Post by kickingfrog on Aug 2, 2015 8:34:39 GMT
Gluten Psychosis: Confirmation of a New Clinical Entity
Posted by Lily on 1/8/2015
GF board
Nutrients.
2015 Jul 8;7(7):5532-9. doi: 10.3390/nu7075235.
Gluten Psychosis: Confirmation of a New Clinical Entity
.
Lionetti E, Leonardi S, Franzonello C, Mancardi M, Ruggieri M, Catassi C
...
Abstract
Non-celiac gluten sensitivity (NCGS) is a syndrome diagnosed in patients with symptoms that respond to removal of gluten from the diet, after celiac disease and wheat allergy have been excluded.
NCGS has been related to neuro-psychiatric disorders, such as autism, schizophrenia and depression.
A singular report of NCGS presenting with hallucinations has been described in an adult patient.
We report a pediatric case of a psychotic disorder clearly related to NCGS and investigate the causes by a review of literature.
The pathogenesis of neuro-psychiatric manifestations of NCGS is unclear.
It has been hypothesized that:
(a) a "leaky gut" allows some gluten peptides to cross the intestinal membrane and the blood brain barrier, affecting the endogenous opiate system and neurotransmission; or
(b) gluten peptides may set up an innate immune response in the brain similar to that described in the gut mucosa, causing exposure from neuronal cells of a transglutaminase primarily expressed in the brain.
The present case-report confirms that psychosis may be a manifestation of NCGS, and may also involve children; the diagnosis is difficult with many cases remaining undiagnosed.
Well-designed prospective studies are needed to establish the real role of gluten as a triggering factor in neuro-psychiatric disorders
**********************************************
Posted by David mc on 1/8/2015
www.direct-ms.org/sites/default/files/Cross%20edit%20neuro%20cel.pdf
I read this article some years ago which connects CD to neurological problems. Psychosis can result from neurological problems, at times caused by certain medications long term usage, something more prevalent in Parkinson's Disease.
Posted by Lily on 1/8/2015
GF board
Nutrients.
2015 Jul 8;7(7):5532-9. doi: 10.3390/nu7075235.
Gluten Psychosis: Confirmation of a New Clinical Entity
.
Lionetti E, Leonardi S, Franzonello C, Mancardi M, Ruggieri M, Catassi C
...
Abstract
Non-celiac gluten sensitivity (NCGS) is a syndrome diagnosed in patients with symptoms that respond to removal of gluten from the diet, after celiac disease and wheat allergy have been excluded.
NCGS has been related to neuro-psychiatric disorders, such as autism, schizophrenia and depression.
A singular report of NCGS presenting with hallucinations has been described in an adult patient.
We report a pediatric case of a psychotic disorder clearly related to NCGS and investigate the causes by a review of literature.
The pathogenesis of neuro-psychiatric manifestations of NCGS is unclear.
It has been hypothesized that:
(a) a "leaky gut" allows some gluten peptides to cross the intestinal membrane and the blood brain barrier, affecting the endogenous opiate system and neurotransmission; or
(b) gluten peptides may set up an innate immune response in the brain similar to that described in the gut mucosa, causing exposure from neuronal cells of a transglutaminase primarily expressed in the brain.
The present case-report confirms that psychosis may be a manifestation of NCGS, and may also involve children; the diagnosis is difficult with many cases remaining undiagnosed.
Well-designed prospective studies are needed to establish the real role of gluten as a triggering factor in neuro-psychiatric disorders
**********************************************
Posted by David mc on 1/8/2015
www.direct-ms.org/sites/default/files/Cross%20edit%20neuro%20cel.pdf
I read this article some years ago which connects CD to neurological problems. Psychosis can result from neurological problems, at times caused by certain medications long term usage, something more prevalent in Parkinson's Disease.