Post by kickingfrog on Feb 23, 2014 18:01:33 GMT
ORIGINAL ARTICLE
The Oslo definitions for coeliac disease and
related terms
Jonas F Ludvigsson et al
ABSTRACT
Objective The literature suggests a lack of consensus on
the use of terms related to coeliac disease (CD) and gluten.
Design A multidisciplinary task force of 16 physicians
from seven countries used the electronic database
PubMed to review the literature for CD-related terms up
to January 2011.
Teams of physicians then suggested
a definition for each term, followed by feedback of these
definitions through a web survey on definitions,
discussions during a meeting in Oslo and phone
conferences. In addition to ‘CD’, the following descriptors
of CD were evaluated (in alphabetical order):
asymptomatic, atypical, classical, latent, non-classical,
overt, paediatric classical, potential, refractory, silent,
subclinical, symptomatic, typical, CD serology, CD
autoimmunity, genetically at risk of CD, dermatitis
herpetiformis, gluten, gluten ataxia, gluten intolerance,
gluten sensitivity and gliadin-specific antibodies.
Results CD was defined as ‘a chronic small intestinal
immune-mediated enteropathy precipitated by exposure
to dietary gluten in genetically predisposed individuals’.
Classical CD was defined as ‘CD presenting with signs
and symptoms of malabsorption. Diarrhoea,
steatorrhoea, weight loss or growth failure is required.’
‘Gluten-related disorders’ is the suggested umbrella term
for all diseases triggered by gluten and the term gluten
intolerance should not to be used. Other definitions are
presented in the paper.
Conclusion This paper presents the Oslo definitions for
CD-related terms
*****************************************
What is already known on this subject?
< There is a lack of consensus on the use of terms
related to coeliac disease (CD) and gluten.
< Variability in the use of terminology has led to
difficulty when comparing and evaluating clinical
studies and research findings.
What are the new findings?
< The panel reached agreement on the definition
of terms related to CD and/or gluten currently in
use in clinical practice and research.
< Some terms in current use should be abandoned
because they are outdated or misleading.
How might it impact on clinical practice in the
foreseeable future?
< Uniform definitions for common terms relating
to CD will improve communication among
researchers, clinicians and the general public,
and will ensure that research is conducted and
reported in a consistent manner.
gut.bmj.com/content/62/1/43.full.pdf+html
The Oslo definitions for coeliac disease and
related terms
Jonas F Ludvigsson et al
ABSTRACT
Objective The literature suggests a lack of consensus on
the use of terms related to coeliac disease (CD) and gluten.
Design A multidisciplinary task force of 16 physicians
from seven countries used the electronic database
PubMed to review the literature for CD-related terms up
to January 2011.
Teams of physicians then suggested
a definition for each term, followed by feedback of these
definitions through a web survey on definitions,
discussions during a meeting in Oslo and phone
conferences. In addition to ‘CD’, the following descriptors
of CD were evaluated (in alphabetical order):
asymptomatic, atypical, classical, latent, non-classical,
overt, paediatric classical, potential, refractory, silent,
subclinical, symptomatic, typical, CD serology, CD
autoimmunity, genetically at risk of CD, dermatitis
herpetiformis, gluten, gluten ataxia, gluten intolerance,
gluten sensitivity and gliadin-specific antibodies.
Results CD was defined as ‘a chronic small intestinal
immune-mediated enteropathy precipitated by exposure
to dietary gluten in genetically predisposed individuals’.
Classical CD was defined as ‘CD presenting with signs
and symptoms of malabsorption. Diarrhoea,
steatorrhoea, weight loss or growth failure is required.’
‘Gluten-related disorders’ is the suggested umbrella term
for all diseases triggered by gluten and the term gluten
intolerance should not to be used. Other definitions are
presented in the paper.
Conclusion This paper presents the Oslo definitions for
CD-related terms
*****************************************
What is already known on this subject?
< There is a lack of consensus on the use of terms
related to coeliac disease (CD) and gluten.
< Variability in the use of terminology has led to
difficulty when comparing and evaluating clinical
studies and research findings.
What are the new findings?
< The panel reached agreement on the definition
of terms related to CD and/or gluten currently in
use in clinical practice and research.
< Some terms in current use should be abandoned
because they are outdated or misleading.
How might it impact on clinical practice in the
foreseeable future?
< Uniform definitions for common terms relating
to CD will improve communication among
researchers, clinicians and the general public,
and will ensure that research is conducted and
reported in a consistent manner.
gut.bmj.com/content/62/1/43.full.pdf+html