Post by kickingfrog on Dec 6, 2011 9:47:52 GMT
Questions and answers on HLA typing and Celiac Disease
Copyright by Michael Jones, Bill Elkus, Jim Lyles, and Lisa Lewis 1995, 1996 - All rights reserved worldwide.
Disclaimer This file is a summary of various posts made on the CELIAC List about genetics and celiac, and more specifically about HLA typing in Celiac Disease.
It has been supplemented by private E-Mail with various experts in this area of CD, and has been reviewed for technical accuracy by Drs. Ludvig Sollid (University of Oslo) and Karoly Horvath (University of Maryland), two of the CEL-PRO experts.
This file is formatted as a question and answer session.
Table of Contents
What are the basic statistics on the risk of Celiac Disease amongst the general population?
What are the basic statistics on the increased risk of Celiac Disease among the various relatives of a diagnosed celiac?
Can genetics testing determine if my sibling will get Celiac Disease?
How common are the Celiac-related HLA markers in the general population? In other words, how specific to Celiac Disease are the Celiac-related HLA markers?
If HLA testing only shows tendencies, why bother doing it at all?
What does HLA mean? How does one test for HLA markers? Where? How much does it cost? Will insurance cover it?
How many different types of HLA markers are there?
Which HLA markers are associated with Celiac Disease? I have been confused, sometimes reading about DQ2, at other times about DR3, B8 and other markers. If one has two copies of the Celiac-related markers instead of one, does it make a difference?
Are there non-HLA genes involved in determining if someone has the potential to get Celiac Disease?
Are there any known HLA or other genetic markers associated with gluten intolerance in autism?
What other disorders is a Celiac more susceptible to due to genetics (as opposed to intestinal damage and/or malabsorption)?
Could my family's genetics be used to advance the scientific knowledge in this area? If so, then who should I contact?
Can you give me some references to read or show my doctor for further details?
Internet references
...
www.enabling.org/ia/celiac/cel-hla.html#Q15
********************
Copyright by Michael Jones, Bill Elkus, Jim Lyles, and Lisa Lewis 1995, 1996 - All rights reserved worldwide.
Disclaimer This file is a summary of various posts made on the CELIAC List about genetics and celiac, and more specifically about HLA typing in Celiac Disease.
It has been supplemented by private E-Mail with various experts in this area of CD, and has been reviewed for technical accuracy by Drs. Ludvig Sollid (University of Oslo) and Karoly Horvath (University of Maryland), two of the CEL-PRO experts.
This file is formatted as a question and answer session.
Table of Contents
What are the basic statistics on the risk of Celiac Disease amongst the general population?
What are the basic statistics on the increased risk of Celiac Disease among the various relatives of a diagnosed celiac?
Can genetics testing determine if my sibling will get Celiac Disease?
How common are the Celiac-related HLA markers in the general population? In other words, how specific to Celiac Disease are the Celiac-related HLA markers?
If HLA testing only shows tendencies, why bother doing it at all?
What does HLA mean? How does one test for HLA markers? Where? How much does it cost? Will insurance cover it?
How many different types of HLA markers are there?
Which HLA markers are associated with Celiac Disease? I have been confused, sometimes reading about DQ2, at other times about DR3, B8 and other markers. If one has two copies of the Celiac-related markers instead of one, does it make a difference?
Are there non-HLA genes involved in determining if someone has the potential to get Celiac Disease?
Are there any known HLA or other genetic markers associated with gluten intolerance in autism?
What other disorders is a Celiac more susceptible to due to genetics (as opposed to intestinal damage and/or malabsorption)?
Could my family's genetics be used to advance the scientific knowledge in this area? If so, then who should I contact?
Can you give me some references to read or show my doctor for further details?
Internet references
...
www.enabling.org/ia/celiac/cel-hla.html#Q15
********************