Post by kickingfrog on Oct 11, 2011 11:04:31 GMT
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Genetic Risk Factors for Celiac Disease
Posted on August 18, 2011
Dr. Eric Stoopler
Associate professor of oral medicine
University of Pennsylvania
Philadelphia, PA
J Can Dent Assoc 2011;77:b107
...
Two HLA molecules, specifically HLA-DQ2 and HLA-DQ8, have been identified as genetic risk factors for CD.2,3
Published reports state that 90%–95% of patients with CD carry the serologically defined HLA-DQ2 heterodimer, while the remaining 5%–10% who are HLA-DQ2-negative demonstrate an HLA-DQ8 heterodimer.3
In addition, inheritance of specific HLA alleles may influence disease phenotype and prognosis.3
Patients demonstrating homozygosity for HLA-DQ2 may be at risk for developing more severe complications related to CD.2,3 CD is highly unlikely in cases where both HLA-DQ2 and HLA-DQ8 are absent, which may assist in diagnostic evaluation for this disease.2
It should be noted that CD is a multigenic disorder with non-HLA alleles contributing genetic polymorphisms to the disease.2
Also, the practical clinical application of HLA typing has yet to be fully determined and may be most useful in screening high-risk groups for CD (as described by the authors) or cases where the diagnosis of CD remains uncertain (i.e., non-specific histologic changes demonstrated on biopsy).3 Currently, HLA typing may be considered as an adjunctive serologic test to standard TTG and EMA analysis for patients with suspected CD.3 ....
www.jcda.ca/article/b107/
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Genetic Risk Factors for Celiac Disease
Posted on August 18, 2011
Dr. Eric Stoopler
Associate professor of oral medicine
University of Pennsylvania
Philadelphia, PA
J Can Dent Assoc 2011;77:b107
...
Two HLA molecules, specifically HLA-DQ2 and HLA-DQ8, have been identified as genetic risk factors for CD.2,3
Published reports state that 90%–95% of patients with CD carry the serologically defined HLA-DQ2 heterodimer, while the remaining 5%–10% who are HLA-DQ2-negative demonstrate an HLA-DQ8 heterodimer.3
In addition, inheritance of specific HLA alleles may influence disease phenotype and prognosis.3
Patients demonstrating homozygosity for HLA-DQ2 may be at risk for developing more severe complications related to CD.2,3 CD is highly unlikely in cases where both HLA-DQ2 and HLA-DQ8 are absent, which may assist in diagnostic evaluation for this disease.2
It should be noted that CD is a multigenic disorder with non-HLA alleles contributing genetic polymorphisms to the disease.2
Also, the practical clinical application of HLA typing has yet to be fully determined and may be most useful in screening high-risk groups for CD (as described by the authors) or cases where the diagnosis of CD remains uncertain (i.e., non-specific histologic changes demonstrated on biopsy).3 Currently, HLA typing may be considered as an adjunctive serologic test to standard TTG and EMA analysis for patients with suspected CD.3 ....
www.jcda.ca/article/b107/
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