Post by kickingfrog on Jan 18, 2011 10:07:41 GMT
Research: Clinical trial: B vitamins improve health in patients with coeliac disease living on GFD
Posted by Jos on 5/12/2010
GF board
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Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet.
C. HALLERT1,
M. SVENSSON2,
J. THOLSTRUP3,
B. HULTBERG4
Article first published online: 20 JAN 2009
DOI: 10.1111/j.1365-2036.2009.03945.x
Summary
Background Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status.
Aim To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease.
Methods In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45–64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status.
Results Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 ìmol/L (7.4–23.0), significantly higher than in matched population controls [10.2 ìmol/L (6.7–22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being.
Conclusions Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet.
onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2009.03945.x/abstract